地塞米松联合垂体后叶素治疗咯血疗效分析

Analysis of Dexamethasone with Pituitrin in Combinative Therapy with Hemoptysis

目的评价地塞米松加硝酸甘油联合治疗咯血的疗效。方法应用地塞米松加垂体后叶素联合治疗咯血50例定为联合治疗组,并把同期应用垂体后叶素单药治疗咯血50例定为对照组,对比分析其疗效及不良反应。结果在治疗48 h后显示:联合治疗组疗效优于对照组,差异有统计学意义。在控制大咯血时,联合治疗组有效率83.3%,对照组有效率66.7%,差异有统计学意义(P<0.05);在控制中量咯血时,联合治疗组有效率75.0%,对照组有效率58.3%,差异有统计学意义(P<0.05);在控制小咯血时,联合治疗组有效率93.8%,对照组有效率68.8%,差异有统计学意义(P<0.05)。结论地塞米松联合垂体后叶素治疗咯血较垂体后叶素单药疗效明显提高,不良反应明显减少。

Objective To assess the curative effect of dexamethasone with pituitrin in combinative therapy on the patients with hemoptysis. Methods Fifty patients（combinative group） with hemoptysis received the combinative therapy of dexamethasone and pituitrin,while fifty pastients（control group） with hemoptysis received the single therapy of pituitrin.Comparisons were made between two groups in curative effect and adverse reactions. Results After 48 hours＇ treatment,the total curative effect of comabinative group was significantly higher than that of control group.In controlling massive hemaoptysis,the effective rates were 83.3% in combinative group and 66.7% in control group（P0.05）,In controlling moderate hemaoptysis,the effective rates were 75.0% in combinative group and 58.3% in control group（P0.05）,In controlling mild hemaoptysis,the effective rates were 93.8% in combinative group and 68.8% in control group（P0.05）.there was not significantly difference between two groups in adverse reactions. Conclusion dexamethasone with pituitrin is more effective with less adverse reactions than single pituitrin in treating hemoptysis.