甲状腺机能亢进症患者24小时尿VMA含量变化

Changes of Urinary Vanillylmandelic Acid Contents per 24 Hours in Patients with Hyperthyroidism.

对30名甲亢未治患者及30名正常对照者测定24小时尿VMA,结果甲亢未治组与正常对照组24小时尿VMA均值分别为51.51±25.72μmol/L,46.72±16.95μmol/L;两组比较,P>0.05,差异无显著性。将血清T3、T4值分别与24小时尿VMA值计算其相关系数,r=0.171和r=0.308,相关均无显著性(P>0.05)。

Using a modification of the fluorometric method, we have measured the urinary vanillyimandelic acid (VMA)/24 hours in 33 patients with hyperthroidism and in 30 normal controls. The results showed that Their urinary VMA concentrations were similaras in normal controls (Their ranges were 15.14～111.99μmol/L and 23.21μ~101.40μmol/L respectively; their mean±SEM were 51.51±25.77μmol/L and 46.72 + 16.951xmol/L respectively). There was no significantdifference in urinary VMA in hyperthyroidism patients and normal controls (P>0.05). And there was no striking relationship between urinary VMA and serum T_3、 T_4 in hyperthyroidism patients(r=0.171, r=0.338, P>0.05). Cateeholamine are regarded to the major end product of VMA. Urinary VMA measurements provided the index of catecholamine release and plasma catecholamine concentrations. These data indicate that many of the signs and symptoms of bypeoidism ratients appear to reflect altered sympathetic nervous system activity. This may be the rcsult of the increase of hypersen-sitiveness in. β-adrenergic recepter.