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基质金属蛋白酶12、Toll样受体2在慢性阻塞性肺疾病临床应用中的研究进展 被引量：1

Progress of study on matrix metalloproteinase-12 and toll-like receptor 2 in clinical application of chronic obstructive pulmonary disease
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摘要 基质金属蛋白酶12是一类高度保守的依赖于锌离子的蛋白水解酶,其作用底物是弹性蛋白、Ⅳ型胶原、Ⅰ型胶原、纤维连接蛋白、层粘蛋白等.Toll样受体2是一种跨膜受体,在病原体感染机体中可发挥天然免疫作用.它们在慢性阻塞性肺疾病的发病过程中有着重要作用. Matrix metalloproteinase-12 is a kind of zinc-binding protein-degrading enzymes. Its substrates are flcxible protein, Ⅳ collagen, 1-type collagen, fibronectin, laminin and so on. Toll-like receptor 2 is a member of transrnembrane receptors,which can induce the innate immunity when the body is infected by pathogens. All of them play an important role on the pathogenesis of chronic obstructive pulmonary disease.
作者 瞿香坤 刘超
机构地区 蚌埠医学院第一附属医院呼吸内科
出处 《国际呼吸杂志》 2011年第7期522-525,共4页 International Journal of Respiration
关键词 基质金属蛋白酶 12 TOLL样受体2 慢性阻塞性肺疾病 Matrix metalloproteinase-12 Toll-like receptor 2 Chronic obstructive pulmonary disease
分类号 R563.9 [医药卫生—呼吸系统]
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参考文献20

  • 1Brinckerhoff CE, Matrisian LM. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol, 2002,3:207 214.
  • 2Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer, 2002,2:161-174.
  • 3Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res,2003,92:827- 839.
  • 4Kirn HS, Kirn HJ, Park KG, et al. Alpha lipoic acid inhibits matrix rnetalloproteinase-9 expression by inhibiting NF kappaB transcriptional activity. Exp Mol meal,2007,39:106- 113.
  • 5Sun T, Gao Y, Tan W, et aI. Haplotypes in matrixmet alloproteinase gene cluster on chromosome 11q22 contribute to the risk of lung cancer development and progressin. Clin Cancer Res, 2006,12 : 7009-7017.
  • 6Demedts IK,Morel Montero A, I.ebecque S, et al. Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax,2006,61:196- 201.
  • 7Hashimoto N, Kawabe T, Hara T, et al. Effect of erythromycin on matrix metalloproteinase-9 and cell migration. J Lab Clin Med,2001,137:176-183.
  • 8Takeda K, Kaisho "F, Akira S. Toll like receptors, Annu RevImmunol,2003,21:335- 376.
  • 9Sandor F, Buc M. Toll-like receptors. I. Structure, function and their ligands. Folia Biol(Praha),2005,51:148- 157.
  • 10Seitz M. Toll-like receptors~ sensors of the innate immune system. Allergy,2003,58:1247- 1249.

同被引文献23

  • 1慢性阻塞性肺疾病诊治指南(2007年修订版)[J].中华结核和呼吸杂志,2007,30(1):8-17. 被引量：8240
  • 2龚非力.医学免疫学.2版.北京:科学出版社,2008:264-279.
  • 3Droemann D, Goldmann T, Tiedje T,et al. Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients. Respir Res, 2005,6 : 68.
  • 4Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature, 1997,388 : 394-397.
  • 5Sukkar MB, Xie S, Khorasani NM, et al. Toll-like receptor 2,3, and 4 expression and function in human airway smooth muscle. J Allergy Clin lmmunol, 2006,118 : 641-648.
  • 6Parker LC, Prince LR, Sabroe I. Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clin Exp Immunol, 2007,147 : 199-207.
  • 7Matsumoto M, Funami K, Tanabe M, et al. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol, 2003,171 : 3154-3162.
  • 8Fuchs B, Knothe S, Rochlitzer S,et al. A Toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to Timothy grass pollen antigens. Int Arch Allergy Immunol, 2010,152 : 131-139.
  • 9Seitz M. Toll-like receptors: sensors of the innate immune system. Allergy, 2003,58 : 1247-1249.
  • 10Jin X, Qin Q, Tu L,et al. Glucocorticoids inhibit the innate immune system of human corneal fibroblast through their suppression of toll-like receptors. Mol Vis, 2009, 15: 2435- 2441.

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国际呼吸杂志
2011年 第7期

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