与白介素8有关的炎症细胞在慢性阻塞性肺疾病中研究进展

Research advancement on interleukin-8 with relevant inflammatory cells of chronic obstructive pulmonary disease

慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）它在世界范围内的高发病率和病死率是导致巨大经济和社会负担的主要原因.近期研究表明,白介素8（interleukin-8,IL-8）与COPD的发生密切相关.IL-8作为主要的炎性递质参与了介导气道炎症反应,加速局部炎症的发生发展,可导致气道结构的重塑和气流阻塞的形成,最终对COPD的发生、发展产生影响.本文就IL-8与COPD的关系作一回顾性叙述.

Chronic obstructive pulmonary disease （COPD）is leading cause of morbidity and mortality worldwide and results in an economic and social burden. The late researches showed close association of IL 8, with the onset of COPD. As major inflammatory mediators, IL-8 involve in the inflammatory response of airway, which accelerate the onset and progrcss of local inflammation, result in the structural reconstruction of airway and the formation of airflow obstruction and thereby influence the onset and progress of COPD. This paper reviews the association of IL-8 and COPD.