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英夫利西在儿童克罗恩病中的应用 被引量：1

Application of Infliximab in Children with Crohn′s Disease
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摘要 英夫利西作为一种针对肿瘤坏死因子的单克隆抗体,在儿童克罗恩病(CD)的治疗中已开始应用。许多大的随机对照研究已经显示其对儿童CD的诱导缓解和维持治疗具有良好的疗效,尤其是生长发育的恢复及降低肠切除术的概率,提高患儿的生活质量。英夫利西的治疗方案包括诱导缓解和维持治疗,前者在第0、2、6周以5 mg.kg-1的剂量静脉滴注,后者在缓解后每8周以相同剂量维持治疗。在治疗过程中要注意调整剂量和用药间隔,以避免失效。严重感染、输液反应、药物性红斑狼疮等不良反应也是重点关注的问题,目前英夫利西是否有致癌的可能性并不清楚,需要长期的随访观察。
作者 朱朝敏 彭哲
机构地区 重庆医科大学附属儿童医院感染消化科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2011年第7期477-479,共3页 Journal of Applied Clinical Pediatrics
关键词 克罗恩病 英夫利西 儿童
分类号 R725.7 [医药卫生—儿科]
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参考文献24

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二级参考文献12

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实用儿科临床杂志
2011年 第7期

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