宁夏回族癫痫患者ABCB1 C3435T与癫痫耐药相关性研究

Association between ABCB1 C3435T and Drug-resistant Epilepsy in Ningxia Hui Epilepsy Patients

目的了解宁夏回族癫痫患者ABCB1 C3435T多态性及与癫痫耐药的关系。方法收集宁夏地区回族癫痫患者123例,其中癫痫药物敏感者60例,耐药者63例,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对两组癫痫患者ABCB1基因C3435T位点的多态性进行检测,并分析其与癫痫耐药的关系。结果耐药组CC基因型和C等位基因频率高于敏感组(P<0.01)。结论宁夏回族癫痫患者中ABCB13435CC基因型及C等位基因与癫痫耐药有关,该位点的多态性可能影响癫痫患者对抗癫痫药物的反应性。

Objective To explore the association between ABCB1 C3435T Polymorphism and drug-resistant epilepsy in Ningxia Hui ethnic epileptic patients.Methods 123 Hui ethnic epileptic patients were collected,including 60 drug responsive epilepsy patients and 63 drug-resistant epilepsy patients.Polymerase chain reaction restriction fragment length polymorphism（PCR-RFLP） technique was used to detected ABCB1 C3435T polymorphism.The relationship between ABCB1 C3435T Polymorphism and drug-resistant epilepsy was analyzed.Results CC type and allele C in the drug-resistant group was significantly higher（P0.01） than those in the drug responsive group.Conclusion ABCB1 3435CC genotype and C allele showed relevance to drug-resistant epilepsy in Ningxia Hui population,and these Polymorphism could affect responsive to antiepileptic drugs（AEDs） in epilepsy treatment.