川芎嗪纳米制剂抗大鼠术后腹腔粘连实验研究

Experimental Research on the Preventive Effect of Ligustrazine Nanoparticles on Postoperative Peritoneal Adhesion Rats

目的探讨川芎嗪纳米制剂抗大鼠术后腹腔粘连的作用。方法将大鼠随机分组,共8组。术后观察大鼠一般情况,各组于术后1周和2周取8只观察粘连情况,采用Phillips评分法对腹腔粘连进行分级。结果各组分级评分与模型组比较,1周组与2周组中的川芎嗪纳米中、高剂量组具有较明显的抗术后粘连作用(P<0.05,P<0.01)。且以川芎嗪纳米组降低粘连发生率的作用尤为显著。结论川芎嗪纳米制剂具有较好的抗术后腹腔粘连的作用。

OBJECTIVE To explore the preventive effect of ligustrazine nanoparticles on postoperative peritoneal adhesion rats.METHODS Rats were randomized into 8 groups,1-week group and 2-week group.The general condition of the rats was observed after operation.8 rats from 1 week and 2 week groups were dissected to know their peritoneal adhesion which graded according to Phillips score system.RESULTS Compared with model group,the medium and high dosage of ligustrazine nanoparticles in 1-week and 2-week groups had the preventive effect on postoperative peritoneal adhesion,especially the ligustrazine nanoparticles groups could particularly reduce the incidence of adhesion（P0.05,P0.01）.CONCLUSION tetramethylpyrazine nanoparticles possess obvious preventive effect on postoperative peritoneal adhesion.