板蓝根有效部位的抗病毒药效研究

A Study on Antiviral Effects of the Active Parts from Radix Isatidis

目的考察板蓝根不同提取部位单独使用和组合使用后抗甲型流感病毒A/PR8/34(H1N1)的活性。方法采用体内抗甲型流感病毒A/PR8/34(H1N1)试验,比较板蓝根不同有效部位的抗甲型流感病毒作用。结果板蓝根提取物Ⅰ组、Ⅲ组、Ⅴ组、Ⅵ组、Ⅶ组、Ⅷ组和Ⅸ组可明显延长甲型流感病毒(H1N1)感染小鼠后的存活天数,与模型组比较具有明显差异(P<0.05,P<0.01)。板蓝根提取物Ⅲ组、Ⅴ组、Ⅵ组和Ⅶ组对甲型流感病毒(H1N1)感染的小鼠的保护作用较强,与模型组比较具有显著性差异(P<0.05)。结论板蓝根提取物Ⅰ组、Ⅲ组、Ⅴ组、Ⅵ组、Ⅶ组、Ⅷ组和Ⅸ组对甲型流感病毒(H1N1)感染的小鼠具有一定的保护作用,以板蓝根提取物Ⅲ组、Ⅴ组、Ⅵ组和Ⅶ组作用较佳。

OBJECTIVE To review the antivirus activity of effective extraction from Radix Isatidis on flu virus of type I[A/PR8/34（H1H1）].METHODS Antivirus test on flu virus of type I[A/PR8/34（H1H1）] was adopted to check and compare the activities of different extracts.RESULTS Group Ⅰ,Ⅲ,Ⅴ,Ⅵ,Ⅶ,Ⅷ and Ⅸ can not only obviously prolong the survival time of the mice infected with flu virus of type I,but also have significant differences with the model group（P0.05,P0.01）.Furthermore,there is a great difference between Group Ⅲ,Ⅴ,Ⅵ and the pattern（P0.05）.CONCLUSION The extract Ⅰ,Ⅲ,Ⅴ,Ⅵ,Ⅶ,Ⅷ and Ⅸ of Radix Isatidis can prolong the survival time of mice infected with flu virus of type I to some extent level and give protection for the effected mice.The extract Ⅲ,Ⅴ,Ⅵ and Ⅶ showed more potent activity.