CDICdb:一个疾病-离子通道关联库

CDICdb:Database of Correlations between Disease and Ion Channel

离子通道是镶嵌在生物膜上的蛋白质,提供了离子出入膜的生物孔道。它们不但与许多基本的生理功能相关,现有研究发现它们还与许多疾病的发生发展有密切的关系。疾病-离子通道关联库(DataBase of Correlations between Disease and Ion Channel,CDICdb)实现了依据离子通道查询相关的疾病,以及依据疾病查询相关离子通道和离子通道关联的KEGG库中Pathway通路的信息的功能。利用本数据库提供的关联网络,研究人员可以对离子通道病有更全面的认识。CDICdb是一个关系型数据库,现在可以免费地使用,网址为:http://db.cdicdb.com/channel2disease/index.html。

Ion channels are pore-forming proteins that allow the passive diffusion of ions across biological membranes.They are responsible for various fundamental biological functions,and a large quantity of studies have demonstrated their closer associations with many diseases.Here,we developed a manually curated database,termed CDICdb,which provides comprehensive information between diseases and ion channels.Using the database,users can search ion channels according to ion-based classification,and then obtain related diseases.They can also search a disease to get relevant ion channels and their associated pathway information from KEGG.In addition,the database provides researchers a comprehensive and systematic insight into the pathogenesis of ion channel-induced diseases.CDICdb is a relational database between diseases and ion channels,and is freely available at http：//db.cdicdb.com/channel2disease/.