缬沙坦对高血压早期肾损害患者的疗效观察

The Observation of the Therapeutic Effect of Valsartan on the Essential Hypertension Patients with Early Renal Injury

目的研究缬沙坦对高血压早期肾损害的疗效。方法选取110名高血压并出现早期肾损害患者,口服给予缬沙坦治疗8周,观察、评价缬沙坦降压疗效的同时,收集病人尿样,采用放免法测定治疗前后的尿微量白蛋白(MA)水平。结果给予缬沙坦治疗后,早期高血压肾损害患者的收缩压、舒张压及尿MA水平均显著降低(P<0.01)。结论对高血压早期肾损害患者,缬沙坦可有效降压及保护肾脏功能。

Objective To analyze the therapeutic effect of valsartan on essential hypertension patients with early renal injury.Methods 110 patients with essential hypertension and early kidney injury were treated with valsartan for 8 weeks,the therapeutic effect of the decrease of the blood pressure were observed,at the same time,the urinary microamount albumin（MA） levels were determined by using radioimmunity method before and after valsartan treatment.Results After valsartan treatment,there was significant decrease of the systolic pressure,diastolic pressure and the urinary MA levels in essential hypertension patients with early renal injury.Conclusion Valsartan can control blood pressure and protect the renal function effectively.