抗生素致老年人肾功能指标异常244例分析

Antibiotics-induced Renal Dysfunction in Aged Patients:Analysis of 244 Cases

目的:研究抗生素对老年人肾功能的影响。方法:对我院244例住院老年患者使用抗生素前后的各项肾功能指标进行观察。结果:244例患者,治疗前化验肾功能及血、尿常规各项指标均无差异性,应用抗生素5～7 d后肾功能CRE、BUN、UA 3项指标增高者有198例,占81.1%。结论:老年人肾功能呈生理性减退,应减量给予抗生素治疗。提倡高龄老年人使用正常治疗量的2/3～1/2。

OBJECTIVE：To explore the effect of antibiotics on renal function in aged patients.METHODS：The parameters of renal function of 244 elder inpatients were followed before and after administration of antibiotics.RESULTS：There were no differences among the 244 cases with regard to renal function,blood tests and urine test indicators before treatment by antibiotics;however,after treatment with antibiotics for 5-7 days,the levels of CRE,BUN and UA increased in 198 cases（81.1%）.CONCLUSION：The renal function in elder patients declined physiologically,thus antibiotic therapy should be given at a reduced dose,preferably,at a dose of 2 /3-1 /2 of the normal therapeutic dose.