摘要
目的:探讨精神疾病专科医院药品不良反应(ADR)的特点及规律,促进临床合理用药。方法:采用回顾性分析方法,对我院上报的314例ADR报表,按患者性别、年龄、疾病诊断、给药途径、ADR报表分类及其药品使用情况、ADR涉及器官或系统、引起ADR最多的前10种药物及主要临床表现进行分析。结果:314例ADR患者中,女性多于男性;21~40岁发生率较高;精神分裂症占多数;口服药发生的ADR更常见;一般的ADR占多数;ADR涉及最多的为神经系统;喹硫平的ADR发生率最高。结论:精神疾病专科医院发生的ADR多涉及神经系统,给患者造成的危害较大,临床应给予高度关注与及时治疗。
OBJECTIVE:To probe into the characteristics and regularity of the adverse drug reactions(ADRs) occurred in psychiatric hospital to promote rational clinical drug use.METHODS:By a retrospective analysis,a total of 314 ADR cases reported by our hospital were analyzed with regard to patients' age and sex,diagnosis,route of administration,category of ADR reports,drug use,ADR-involved organs or systems,the top 10 drugs in terms of ADR incidence and the major clinical manifestations.RESULTS:Of the 314 ADR cases,females showed higher proportion than males;patients aged 21-40 years had a higher incidence rate.Schizophrenia patients represented the majority.The ADRs were more often seen in patients after oral medication.The common ADRs represented the majority.Nervous system was the most commonly involved system in the ADRs.Quetiapine had the highest incidence of ADRs.CONCLUSION:Nervous system was the most commonly involved system in the ADRs seen in psychiatric hospital,which cause great harm to patients,thus great attention should be paid to clinically to give timely treatment.
出处
《中国医院用药评价与分析》
2011年第3期272-274,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
报告
分析
Adverse drug reaction(ADR)
Reports
Analysis