SPARC在子宫内膜癌组织中的表达及意义

Expression and Significance of the SPARC Protein in Endometrial Carcinoma

目的:探讨富含半胱氨酸的酸性分泌型蛋白(secreted protien,acidic and rich in cysteine,SPARC)在子宫内膜癌组织中的表达及其临床意义。方法:应用组织芯片技术研究SPARC在正常子宫内膜、增生的子宫内膜和子宫内膜癌组织中的表达情况。结果:SPARC在正常子宫内膜、增生的子宫内膜和子宫内膜癌组织中的阳性表达率分别为96.55%、76.79%、59.50%,差异具有统计学意义(P<0.05)。在子宫内膜癌中,SPARC的表达强度与手术-病理分期、组织学分级、肌层浸润深度和淋巴结转移相关,差异具有统计学意义(P<0.05)。结论:SPARC表达的缺失与子宫内膜癌的发生、发展密切相关,检测SPARC可为子宫内膜癌的早期诊断、进一步治疗及预后判断提供一定的理论依据。

Objective：To investigate the expression of secreted protein acidic and rich in cysteine（SPARC） in endometrial carcinoma.Methods：The expressions of SPARC in normal endometrium,proliferetive endometrium and endometrial carcinoma were analyzed by tissue microarray technique.Results：The positive rate of SPARC protein expression was 96.55 %,76.79 %,59.50 % in normal endometrium,proliferetive endometrium and endometrial carcinoma,respectively,which had statistical significance obviously compared with other groups（P0.05）.In endometrial carcinoma,the expression of SPARC was related to surgical stage,histological grade,myometrial invasion and lymph node metastasis,with a statistical significance（P 0.05）.Conclusions：The expression loss of SPARC protein was related with the generation and development of endometrial carcinoma.Detection of SPARC may provide a certain theory for the early diagnosis,further treatment and prognosis of endometrial carcinoma.