摘要
来源于出血后血红蛋白或衰老细胞释放的血红素能够诱导血红素氧合酶-1(HO-1,HSP-1)的表达。血红素氧合酶-1催化血红素生成气体介质一氧化碳,铁和胆绿素。胆绿素和它的代谢产物胆红素都是有效的抗氧化剂;同时铁诱导的铁蛋白和CO也发挥着各自的保护作用。因此,HO-1的表达被看作一种重要的保护机制。在各种不同的脑病理改变发生后,如蛛网膜下腔出血,脑梗死,创伤性脑损伤及神经变性疾病,HO-1明显表达于小胶质细胞,星形细胞和神经元细胞,从而发挥其重要脑保护作用。
Extracellular heme derived from hemoglobin following hemorrhage or released from dying cells induces the expression of heme oxygenase-1（HO-1,HSP-32） which metabolizes heme to the gaseous mediator carbon monoxide（CO）,iron（Fe） and biliverdin.Biliverdin and its product bilirubin are powerful antioxidants..Meanwhile ferritin induced by iron and CO also play respectively protective effect.Thus,expression of HO-1 is considered to be a protective mechanism.After various kind of brain pathology,such as subarachnoidal hemorrhage,cerebral infraction,tramatic brain injuries and neurodegenerative diseases,HO-1 expresses obviously in microglia,astrocyte and neuron,and plays a critical role.
出处
《现代生物医学进展》
CAS
2011年第5期961-963,共3页
Progress in Modern Biomedicine
基金
兰州军区医药卫生科研基金资助项目(LXH-2007018)
