胺碘酮致甲状腺功能异常的诊治进展

The progress on the diagnosis and treatment of amiodarone-induced thyroid dysfunction

胺碘酮是治疗心律失常的常用药物。但由于其富含碘及自身固有的特性,可导致一系列甲状腺功能的紊乱,甚至引发明显的甲状腺功能减退(甲减)或甲状腺功能亢进(甲亢)。对于胺碘酮所致甲减(AIH)的诊断和治疗目前比较清晰,但对胺碘酮所致甲亢(AIT)的诊断、鉴别其亚型及治疗有一定的难度。

Amiodarone is an effective medication approved for the treatment of cardiac arrhythmias.However,this drug has high iodine content,and this feature plus the intrinsic effects on the body which make amiodarone toxic to the thyroid gland would induce a series of disfunction,even result in overt hypothyroidism or thyrotoxicosis.So far,the diagnosis and treatment of amiodarone-induced hypothyroidism（AIH） is clear and definite,whereas that of amiodarone-induced thyrotoxicosis（AIT） and the ability to distinguish between the subtypes of the diease have much more challenge.And confirming the subtype of AIT is instructive to the treatment.