基质衍生的血管生成抑制剂研究进展

The development of Matrix-derived Angiogenesis inhibitor

血管的生成与肿瘤密切相关,抑制肿瘤血管生成可以调节肿瘤的生长。体内存在着内源性的促血管生成因子和抑制因子的平衡,当促血管形成因子增强就会产生新生血管供肿瘤生长,而当抑制因子增强则会抑制肿瘤的生长。本文即对细胞外基质衍生的内源性血管生成抑制因子TSP、内皮他丁、Arresten;Canstatin、Endorepellin、Fibulin、Tumstatin等的特性、应用和作用机制等作一总结。

Angiogenesis is closely related with tumor,inhibit tumor angiogenesis could regulate tumor growth.There is a balance between pro-angiogenesis and antiangiogenesis,when the pro-angiogenesis express amount,would generate new blood vessel for tumor growth,while antiangiogenesis would inhibit tumor growth.We now have a summary with the characteristics、applications and mechanisms of matrix-derived endogenous inhibitors of angiogenesis,such as TSP、Endostatin、Arresten;Canstatin、Endorepellin、Fibulin、Tumstatin and so on.