美沙酮维持治疗患者滥用苯二氮卓类药物调查与护理

The investigation about benzodiazepine abuse among outpatients receiving methadone maintenance treatment and nursing

目的:调查美沙酮维持治疗者滥用苯二氮卓类药物的发生率及相关因素。方法:对参加美沙酮维持治疗的海洛因依赖者进行尿苯二氮卓及吗啡检测,将苯二氮卓尿检结果与患者性别、婚姻状态、文化程度、滥用海洛因方式、年龄、海洛因滥用时间、美沙酮维持治疗剂量、参加美沙酮维持治疗的时间及尿吗啡检测结果等共九个因素进行Logistic回归分析。结果:共调查160例,尿苯二氮卓阳性率是8.1%,尿吗啡阳性率是36.3%,苯二氮卓阳性与吗啡阳性及注射使用海洛因相关(OR=27.328,P<0.005),与性别、年龄、海洛因依赖时间、服用美沙酮剂量等其他因素无相关性。结论:美沙酮维持治疗者存在滥用苯二氮卓类药物的现象,尤其是注射使用海洛因,并且在治疗期间仍滥用海洛因的患者。

Objective：To investigate the ratio and relation factors of benzodiazepine abuse among outpatients receiving methadone maintenance treatment（MMT）.Methods：Finished urine benzodiazepine and morphine test on patients of MMT,then do the Logistic regression analysis between urine benzodiazepine test results and nine factors,such as sex,marital status,education,the way of drug abuse,age,the dose of methadone,MMT time,the result of urine morphine test.Results：Among 160 cases,the positive rate of benzodiazepine and morphine were 8.1%,36.3% respectively.The benzodiazepine abuse was positive interrelated with heroin abuse and injecting drug abuse,not relevant with other factors.Conclusion：Benzodiazepine abuse,was exist in MMT clinic,especially exist among patients which still injecting abuse heroin.