血清内脂素水平与2型糖尿病的关系

Correlation between serum level of visfatin and type 2 diabetes mellitus

目的 探讨血清内脂素（visfitin）水平与2型糖尿病（T2DM）之间的相关性.方法 采用酶联免疫吸附（ELISA）法对临床上糖调节受损（IGR）40例患者（IGR组）、T2DM 106例患者（T2DM组）和健康对照者86例（对照组）进行空腹血清visfatin水平的检测.结果 空腹血清visfatin水平在IGR组[（19.93±6.89）μg/L]、T2DM组[（29.53±11.33）μg/L]依次增高,且与对照组[（16.12±5.24）μg/L]相比均显著增高（P＜0.01）;空腹血清visfatin水平与腰臀比呈正相关（r=0.161,P＜0.05）,与三酰甘油、低密度脂蛋白胆固醇、糖化血红蛋白、空腹血糖、空腹胰岛素、lg稳态模型胰岛素抵抗指数（HOMA-IR）呈显著正相关（r=0.189、0.266、0.643、0.574、0.285、0.526,P＜0.01）,与高密度脂蛋白胆固醇呈显著负相关（r=-0.377,P＜0.01）;以visfatin为应变量进行多重线性回归分析,糖化血红蛋白（β=0.512,P=0.000）、lgHOMA-IR（β=0.172,P=0.026）、腰臀比（β=0.119,P=0.036）进入方程.结论 visfatin可能参与了血糖、血脂代谢的调节,且与胰岛素抵抗密切相关;visfatin可能是T2DM的危险因素之一.

Objective To investigate the correlation between serum level of visfatin and type 2 diabetes mellitus （T2DM）. Methods Impaired glucose regulation （IGR） group consisted of 40 patients,T2DM group consisted of 106 patients, while control group consisted of 86 subjects. The serum visfatin levels of all groups were detected by enzyme linked immunosorbent assay （ELISA）. Results Fasting serum visfatin levels in IGR group and T2DM group were significantly higher than those in control group [（19.93 ±6.89） μg/L and （29.53 ± 11.33） μg/L vs. （16.12 ± 5.24） μ g/L, P 〈 0.01]. Fasting serum visfatin levels positively correlated with waist-to-hipratio （WHR） （r = 0.161, P 〈 0.05）; significantly positively correlated with triacylglycerol （TG）, low density lipoprotein cholesterol （LDL-C）, glycosylated hemoglobin （HbA1c）,fasting plasma glucose （FPG）, fasting insulin （FINS）, lg Homeostasis model assessment-insulin resistance index （HOMA-IR） （r = 0.189,0.266,0.643,0.574,0.285,0.526,P 〈 0.01）, and significantly negatively correlated with high density lipoprotein cholesterol （HDL-C）（r =-0.377,P 〈0.01）. When visfatin was analyzed as a dependent variable in multiple linear regression, HbA1c （β = 0.512, P = 0.000）, lg HOMA-IR （β= 0.172, P = 0.026）, WHR （β = 0.119, P = 0.036） were into the equation. Conclusion Visfatin may be involved in glucose and lipid metabolism regulation, and closely related with insulin resistance; visfatin may be a risk factor for T2DM.