慢性阻塞性肺疾病患者血清同型半胱氨酸分析

Detection and analysis of homocysteine in patients with chronic obstructive pulmonary disease

目的 分析血清同型半胱氨酸（Hcy）在慢性阻塞性肺疾病（COPD）急性加重期中的变化及可能的致病原因.方法 选取2007年3月至2010年9月入住北京朝阳医院呼吸科的COPD急性加重期患者208例为COPD组;选取同期进行健康体检的60例健康人作为健康对照组.观察2组血清中的Hcy水平变化情况.结果 COPD急性加重期患者血清中Hcy为（19.20±7.11）μmol/L,阳性率为53.8%（112/208）;健康对照组血清Hcy为（7.67±4.33）μmol/L,阳性率为5.O%（3/60）,2组Hcy水平与阳性率比较,差异有统计学意义（P＜0.01）.结论 COPD急性发作期患者血清中Hcy水平升高,考虑可能与COPD急性发作期患者血液易出现高凝状态或血栓前状态有关.

Objective To investgate the change of the serum homocysteine in patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）, and to explore the possible cause of the change. Methods Patients with AECOPD （n =208 ） were collected in respiratory department of Beijing Claoyang hospital from March 2007 to September 2010, healthy people in medical clinic of Beijing Chaoyang hospital （ n = 60） were enrolled as control group. We observed the changes of the serum homocysteine in this AECOPD group and control group.Results The serum homocysteine in patients with AECOPD was （19.20 ± 7.11 ）μmol/L and the positive rate was 53.85% （112/208）; meanwhile the serum homocysteine of control group was （7.67 ±4.33） μ mol/L, with a positive rate of 5.0% （3/60）. There was a significant difference between the two groups （ P 〈 0.01 ）. Conclusion There is an increase in the serum homocysteine in patients with AECOPD, which may be caused by the blood hypercoagulable state and prothrombotic state of AECOPD patients.