芪苈强心胶囊对心气虚型慢性心力衰竭大鼠心功能的影响

Influence of Qiliqiangxin capsule on cardiac function in rats with chronic heart failure of Heart Qi deficiency

[目的]观察芪苈强心胶囊对心气虚型慢性心力衰竭大鼠气虚证候以及左心室结构和功能的影响。[方法]采用结扎大鼠冠状动脉左前降支,心肌梗死8周后形成心气虚型慢性心力衰竭模型,随机分为假手术组、模型组、芪苈强心胶囊低、中、高(0.25、0.5、1.0 g/kg)剂量组、缬沙坦组。连续给药4周后,测定心气虚证评价指标,包括心率、呼吸频率、力竭游泳时间,同时采用超声心动仪分别测定大鼠左心室结构和功能指标[;结果]芪苈强心胶囊各剂量组均可不同程度的改善心力衰竭大鼠的心率、呼吸频率及力竭游泳时间,降低大鼠左室舒张末期内径(LVDd)、左室收缩末期内径(LVDs),升高左室舒张末期室间隔厚度(LVSd)、左室收缩末期室间隔厚(LVSs)、左室舒张末期后壁厚度(LVPWd)、左室收缩末期后壁厚度(LVPWs),改善左室射血分数(EF)、左室短轴缩短率(FS),降低左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV),与模型组比较差异显著(P<0.05,P<0.01)。[结论]芪苈强心胶囊可改善心气虚型慢性心力衰竭大鼠气虚证候,缓解左心室结构异常,增强心功能,其中芪苈强心胶囊高剂量组(1.0g/kg)效果明显。

[Objection] To observe the effect of Qiliqiangxin capsule on the structure of left ventricular structure and function in rats with chronic heart failure（CHF） of Heart Qi deficiency and its effect on the syndrome of Heart Qi deficiency.[Methods] The anterior descending coronary artery was ligated in rats,CHF was caused by myocardial infarction and Heart Qi deficiency was formed after 8 weeks after that.The rats were randomly divided into sham operation group,model group,Qiliqiangxin capsule of 0.25,0.5,1.0 g/kg group,and valsartan group.After treating for 4 weeks the heart rate,respiratory rate,exhaustive swimming time was evaluated and the echocardiography instrument was used to measure the left ventricular function and structure.[Results] Qiliqiangxin capsule could improve the heart rate,respiratory rate and swimming time in different degrees.It could also decrease LVDd,LVDs,LVEDV,LVESV,while increasing LVSd,LVSs,LVPWd,LVPWs and EF,FS in different degrees.There were significant differences between the Qiliqiangxin capsule and model group（P0.05,P0.01）.[Conclusion] Qiliqiangxin capsule can improve the symptoms of heart Qi deficiency,ameliorate the abnormality of the ventricular cardiac structure,and increase the heart function of CHF with heart Qi deficiency in rats.High dose group of Qiliqiangxin capsule is more superior than other dose groups.