Labrasol对灯盏花素角膜透过率的影响

Effects of Labrasol on the corneal permeability for Breviscapinun

[目的]研究Labrasol对灯盏花素角膜透过率的影响,探讨其在眼用制剂中的应用。[方法]采用离体角膜渗透技术考察不同浓度的Labrasol对灯盏花素兔角膜透过率的影响。[结果]Labrasol质量浓度为0.5%、1.0%、1.5%、2.0%、3.0%时,使灯盏花素的表观渗透系数分别增加了2.41倍、4.11倍、4.18倍、4.14倍、2.86倍,与对照组比都有显著性差异(P<0.01),而质量浓度为5.0%时未能显著增大灯盏花素的表观渗透系数(P>0.01)。[结论]质量浓度为0.5%～2%的Labrasol均能显著性的增加灯盏花素的角膜透过量,且对角膜无刺激性。

[Objective] To investigate the effect of Labrasol on the corneal permeability for Breviscapinun and explore its use in ophthalamologic preparation.[Methods] The effects of Labrasol on the corneal permeability for breviscapinun were investigated in vitro,using isolated rabbit corneas.[Results] In the presence of Labrasol at a con centration between 0.5% and 5.0%,the maximum apparent permeability coefficient（Papp） was 2.41,4.11,4.18,4.14,and it was 2.86folds for breviscapinun,respectively,compared with control（P0.01）,However,5.0% Labrasol could not improve the appeared permeability for breviscapinun（P0.01）.[Conclusion] labrasol at 0.5%~2.0% has potential clinical benefits in improving the ocular drug delivery of breviscapinun and has not irritation to eye tissues.