有机硒牛磺酸制剂辐射防护作用小鼠试验研究

Study on the Antiradiation Effect of Organic Selenium and Taurine

采用60Coγ射线全身照射清洁级昆明种小鼠,观察口服给予有机硒牛磺酸制剂对小鼠30天存活情况、骨髓有核细胞数和微核、超氧化物歧化酶(SOD)活力和谷胱甘肽过氧化物酶(GSH)活性、免疫功能的影响。试验结果显示:与单纯照射组相比,给药组小鼠30天存活率提高显著,平均存活天数提高7.9 d;给药组GSH和抗体积数升高显著;中剂量和高剂量SOD活性增强;高剂量脾脏系数升高显著。

Radiation protection effect was studied of organic selenium and taurine on KM mice irradiated by 60Co gamma ray.The results show that organic selenium and taurine could increase 30 d survival rate,averaged 7.9 days.GSH and antibody cumulation values of serum hemolysin（ACVH） were significantly higher.SOD was increased in mice treated with high dose and middle dose.Weight ratio of spleen versus body was significantly higher in mice treated with high dose.