期刊文献+

猪胰岛移植物制备与异种移植治疗糖尿病 被引量:1

下载PDF
导出
摘要 目的 增加胰岛收获量及减少移植后的宿主免疫排斥, 异种移植治疗糖尿病。方法 利用机械法分离成年猪胰岛, 葡聚糖离心纯化, 移植物用羊膜囊包裹移植于糖尿病人大网膜。结果 每个成年猪胰腺可收获胰岛61~90 万个, 纯度达90% ; 胰岛形态完整, 对葡萄糖刺激反应胰岛素释放量是基础分泌的4 倍; 异种移植后病人不用免疫抑制剂即可保持正常血糖1~3 月, 半年后仍可减少胰岛素用量60% ~80% 。
出处 《云南医药》 CAS 1999年第5期324-325,共2页 Medicine and Pharmacy of Yunnan
  • 相关文献

参考文献4

二级参考文献4

  • 1胡远峰,中华器官移植杂志,1990年,11卷,50页
  • 2夏穗生,中华器官移植杂志,1988年,9卷,105页
  • 3周德猷,中华内分泌代谢杂志,1988年,4卷,73页
  • 4刘新民,中华器官移植杂志,1985年,6卷,55页

共引文献9

同被引文献19

  • 1张伟杰,姜汉英.猪胰岛移植物的大量制备[J].中华器官移植杂志,1993,14(4):151-153. 被引量:9
  • 2Zulewski H,Abraham E J, Gerlach M J, et al. Multipotential nestin postive stem cells isolated from adult pancreatic islets differentiate exvivo into pancreatic endocrin, exocrine, and hepatic phenotypes. Diabetes, 2001,50:521~533.
  • 3Brendel MD, Hering BJ, Schultz AO,et al. International Islet Transplant Registry:Newsletter No 9,2001.
  • 4Thomson JA, Itskovitz-Eldor J,Shapiro SS, et al.Embronic stem cell Lines derived from human blastocysts. Science,1998,282:1 145-1 147.
  • 5Soria B, Roch E,Berna G, et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes,2000,49:157-162.
  • 6Assady S, Maor G, Amit M,et al. Insulin production by buman embryonic stem cells. Diabetes,2001,50:1 691-1 697.
  • 7Bogdani M,Lefebvre V, Buelens N, et al. Formation of insulin-positive cells in implants of human pancreatic duct cell preparations from young donors. Diabelologia,2003,46:830-838.
  • 8Bonner-Weir S, Taneja M, Weir G, et al. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA,2000,97:7 999-8 004.
  • 9Yang LJ,Li SW, Hatch H, et al.In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci USA,2002,99:8 078-8 083.
  • 10Hori Y, Rulifson IC, Tsai BC, et al. Growth inhibitors promote differentiatian of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci USA,2002,99:16 105-16 110.

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部