特发性中枢性性早熟女童血循环骨骼生长标志物NTproCNP水平测定

Determation of NTproCNP of the mark of bone growth in idiopathic central precocious puberty

【目的】探求特发性中枢性性早熟儿童血浆骨骼生长标志物NTproCNP水平变化,以及其与IGF-I和雌二醇之间的关系。【方法】16名特发性中枢性性早熟女童及16例年龄相当的正常女童为研究对象,测量身高、体重,计算骨龄。骨龄评价采用TW2法。ELISA测定血清IGF-I和C型钠尿肽前体氨基末端肽(NTproCNP);化学发光法测定雌二醇。【结果】特发性中枢性性早熟女童与正常对照组女童血浆NTproCNP水平分别为(18.92±8.62)pmol/mL和21.74(13.12)pmol/mL(Z=2.34,P<0.05);血清IGF-I水平分别为(867.50±318.15)ng/mL和(522.41±228.33)ng/mL(t=3.59,P<0.05);血清雌二醇水平分别为(37.19±16.08)pg/mL和19.00(4.5)pg/mL,差异均有统计学意义(Z=2.58,P<0.05)。血浆NTproCNP水平与血清IGF-I无相关性,二者与雌二醇也无相关性。【结论】特发性中枢性性早熟女童血循环骨骼生长标志物NTproCNP升高。

【Objective】 To explore the features of plasma NTproCNP and the relationship during NTproCNP,IGF-Ⅰ and estrogen in girls with idiopathic central precocious puberty. 【Methods】 A total of 16 cases of girls with idiopathic central precocious puberty（ICPP） were set as ICPP group,while the control group involved 16 healthy girls with age matched.Physical detection indices such as height,body weight and bone age were determined.The bone age was measured with TW2 method,through evaluating the ossification center of the left hand and wrist.Plasma NTproCNP and IGF-Ⅰ were measured by ELISA,while estrogen（E2） was determined by chemoluminescence assay. 【Results】 In both the control group and ICPP group,plasma NTproCNP levels were（18.92±8.62） pmol/mL and 21.74（13.12）pmol/mL,respectively（Z=2.34,P0.05）.The serum IGF-I levels were（522.41±228.33） ng/mL and（867.50±318.15） ng/mL,respectively（t=3.59,P0.05）.The serum estrogen levels were 19.00（4.5） pg/mL and（37.19± 16.08） pg/mL,respectively（Z=2.58,P0.05）.In both ICPP group and control group,plasma NTproCNP level had no correlation with neither age nor bone age;moreover,plasma NTproCNP had no correlation with IGF-Ⅰ;no correlation was found between NTproCNP,IGF-Ⅰ and estrogen. 【Conclusion】 The plasma NTproCNP level is significant rising in the girls of ICPP.