特发性中枢性性早熟女童乳房发育年龄与母亲初潮年龄及身高相关性研究

Relationship between breast development age of idiopathic central precocious puberty girl and maternal age at menarche and maternalheight

【目的】探讨特发性中枢性性早熟(idiopathic central precocious puberty,ICPP)女童乳房发育年龄与母亲初潮年龄及母亲身高间的关系。【方法】采用回顾性调查方法,并测查身高、体重第二性征、子宫卵巢、B超及促性腺激素释放激素刺激实验,对ICPP组、单纯性乳房早发育(simple premature thelarche,SPT)组及正常对照组进行研究,并进行相关性分析。【结果】1)ICPP女童的母亲月经初潮年龄(11.66±1.35)岁显著低于SPT组(12.93±1.66)岁和正常对照组(14.03±0.58)岁(P<0.01);2)ICPP女童母亲身高(154.13±3.61)cm显著低于SPT组(159.80±4.71)cm及正常对照组(159.50±2.33)cm(P<0.01);SPT组与正常对照组比较差异无统计学意义;3)ICPP组女童的乳房开始发育年龄与母亲月经初潮年龄、母亲身高均具有显著直线正相关(P<0.01)。【结论】特发性中枢性性早熟女童乳房发育年龄与母亲初潮年龄及身高关联性大;特发性中枢性性早熟女童及母亲的身材矮小与性早熟或青春期提前有关。

【Objective】 To study the association between breast development age of idiopathic central precocious puberty（ICPP） girl and maternal age at menarche and maternal Height. 【Methods】 1） ICPP group included 43 cases and SPT group included 41 cases and 30 cases as control group.2）Compared the maternal age at menarche and height among ICPP,SPT and control groups.3）Linear correlation analysis was made between the age of breast development and maternal age at menarche and height in ICPP girls. 【Results】 1）Maternal age at menarche in ICPP group were significantly lower than SPT group[（11.66±1.35）ears vs（12.93±1.66）ears,P0.01] and than control group[（11.66±1.35）ears vs（14.03±0.58）ears,P0.01）.There was no significantly difference of them between SPT and control group（P0.05）.2）The maternal height in ICPP group was significantly lower than both SPT and control group[（154.13±3.61）cm vs（159.80±4.71）cm,（154.13±3.61）cm vs（159.5±2.33）cm P0.01 respectively].3）There were significanly linear correlation between the age at breast development and maternal age at menarche and height in ICPP（P0.01,respectively）. 【Conclusions】 1）Breast development age of idiopathic central precocious puberty（ICPP） girl has a large correlation with maternal age at menarche and maternal height.2）Short stature of ICCP girl and mother may have correlation with their early puberty or ICPP.