地塞米松致呃逆不良反应分析

Analysis of dexamethasone-induced hiccup

目的:探讨地塞米松与呃逆之间的关联性及对抗呃逆的有效治疗措施。方法:检索全军ADR监测中心数据库,收集2004年1月1日-2010年3月31日地塞米松导致呃逆的ADR报告,对患者的一般情况、用药情况、呃逆临床表现及处理转归进行调查分析,并通过对国内外有关地塞米松导致呃逆的个案报道文献的分析加以佐证。结果:数据库检索到地塞米松导致呃逆ADR报告11例,其中男性10例(90.91%),女性1例(9.09%),平均(47.55±14.56)岁,均有时间关联性,去激发后均改善,1例再激发阳性,8例排除患者病情及并用药品影响;文献检索到病例报告共37例,男性32例(86.49%),女性5例(13.51%),平均年龄(38.97±16.76)岁,均有时间关联性,去激发后均改善,7例再激发阳性,10例有地塞米松致呃逆既往史。结论:地塞米松可导致呃逆,严重者可见持久性或顽固性呃逆,应用山莨菪碱、针灸及中药汤剂治疗能有效缓解症状。

Objective：To investigate the correlation between dexamethasone and hiccup and to explore its effective therapy for hiccup.Methods：The data were collected from The PLA ADR Monitoring Center from January 1,2004 to March 31,2010.Hiccup induced by dexamethasone was analyzed in respect of general condition of patients,drug usage,clinical manifestations,treatment of turnover and prognosis,which was verified by the analysis of the published literatures about dexamethasone-induced hiccup.Results：There were 11 cases of hiccup induced by dexamethasone searched from database with 10 men（90.91%） and 1 woman（9.09%）,and the average age was（47.55±14.56） years.The symptom of hiccup improved after withdrawl of dexamethasone,which showed that the occurrence of hiccup was related with time.One case was positive after excitation,and 8 cases excluded the influence of disease and the combination drugs.There were 37 literatures about hiccup induced by dexamethasone with 32 males（86.49%） and 5 females（13.51%）,and the average age was（38.97±16.76） years.The occurrence of hiccup associated with the use of dexamethasone,and the symptom improved after withdrawl of dexamethasone with 1 positive case after excitation and 10 cases of dexamethasone-induced hiccup history.Conclusion：Dexamethasone could lead to hiccup even persistent hiccup or intractable hiccup,which can be relieved by anisodamine,acupuncture and moxibustion and herbal soup.