肾康注射液与普通胰岛素注射液合用致过敏反应

Hypersensitivity due to combination use of Shenkang injection and insulin injection

1例42岁男性患者,慢性肾功能不全8年,既往无药物和食物过敏史。治疗期间患者单独使用肾康注射液及普通胰岛素注射液,未出现不良反应。当给予肾康注射液100 mL+5%葡萄糖注射液250 mL+普通胰岛素2 IU静滴,滴速60滴.min-1,10 min后,患者出现全身皮肤瘙痒,斑片状风疹,略高于皮肤表面,双上肢、头及颈部较严重,无呼吸困难。立即停药,给予抗过敏治疗,20 min后未再出现皮肤瘙痒,仍有皮肤斑片状风疹。1 d后症状好转,其余药品继续使用,未再发生类似反应。

A 42-year-old man,diagnosed as nephropathy for 8 years and had no allergic history,was given Shenkang injection and insulin injection separately during the treatment,and there was no adverse reaction.Then the patient was intravenously given an infusion of Shenkang injection 100 mL plus 5% glucose 250 mL and insulin 2 IU,with the speed of 60 drops per minute.Ten minutes later,the patient presented with whole skin itch and piece-like rubella which was higher appreciably than skin especially in arms,head and neck,but no dyspnea.The drugs was stopped immediately,and anti-allergic therapy was conducted,the itch disappeared and the rubella subsidised in 20 minutes.One day later,the symptom took a favorable turn and similar reaction was not detected any more.