黄体中期子宫内膜活检在诊断黄体功能中的意义

The significance of endometrial biopsy during luteal median phase in diagnosis of luteal function

目的 对原因不明的不孕症及反复流产患者的黄体期行不同时间子宫内膜活检，寻找患者不孕的原因，并观察内膜活检在诊断卵巢黄体功能上的意义。方法 对５３ 例不孕症患者进行了黄体中期血孕酮检测和黄体中、晚期子宫内膜活检。结果 ５３ 例患者中２４ 例子宫内膜分泌延迟都发生在黄体中期。其中９ 例内膜分泌延迟一直持续到晚期，这些患者的平均血孕酮值较正常组明显偏低（ Ｐ＜０．０５） 。另１３ 例晚期内膜分泌转为正常，其平均血孕酮值正常，与正常组差异无显著性（ Ｐ＞０ ．０５）。余２９ 例患者黄体中、晚期子宫内膜活检均正常。结论 黄体中期子宫内膜活检更易发现患者不孕的原因。黄体中、晚期内膜活检均表现分泌延迟者，提示其黄体功能低下，黄体中期分泌延迟晚期正常者黄体功能似乎正常。

Objective To investigate the significance of progesterone profile and endometrial biopsy during luteal median phase in diagnosis of luteal function. Methods The progesterone profile during median luteal phase and endometrial histology during median and late luteal phase of 53 infertile women with infertile and recurrent abortion for unknown reasons were studied. Results Retarded endometrial development occurred in the median luteal phase in 24 of the 53 cases, 9 of which lasted into the late phase. The average progesterone profile of these patients was markedly lower compared with the control group ( P <0.05). However, the average progesterone profile remained normal in the other 13 cases, in whom, RED got normalized in the late luteal phase. Endometrial biopsies taken during the median and late luteal phase from the rest of 29 cases were normal. Conclusions In patients with retarded endometrial development during the full luteal phase, luteal function was decreased, but in patients with retarded endometrial development only during the median luteal phase, luteal function appeared to be normal.