2006—2008年冬春季乌鲁木齐市呼吸道感染住院患儿病毒病原研究

Research of viral pathogens in hospitalized children with respiratory infection in Urumuqi in two consecutive epidemic seasons from 2006 to 2008

目的了解冬春季呼吸道感染住院患儿中7种常见呼吸道病毒的感染状况。方法采集2006年11月至2007年5月及2007年11月至2008年5月于新疆维吾尔自治区人民医院儿科住院的共479例呼吸道感染患儿的鼻咽分泌物,用直接免疫荧光方法,检测呼吸道合胞病毒(RSV)、腺病毒(ADV)、甲型流感病毒(IfuA)、乙型流感病毒及副流感病毒Ⅰ、Ⅱ、Ⅲ(ParaⅠ、Ⅱ、Ⅲ)型7种常见呼吸道病毒抗原。结果 2006—2007年冬春季7种病毒阳性检出率为24.3%,2007—2008年冬春季阳性检出率为41.8%。2年冬春季7种病毒中RSV检出率均占首位,分别为20.1%及32.3%。结论 RSV感染是新疆维吾尔自治区人民医院冬春季呼吸道感染住院患儿的最主要呼吸道病毒病原。ADV及ParaⅢ型感染位居第二、三位,而其他4种病毒感染少见。

Objective To explore the characteristics of viral pathogens in hospitalized children with respiratory infection in Urumchi.Methods 479 nasopharyngeal secretion samples were collected from the hospitalized children with respiratory infection in the People’s General Hospital of Xinjiang Uygur Autonomous Region respectively from November 2006 to April 2007 and from November 2007 to April 2008.Direct immunofluorescence was done to detect seven common respiratory viruses,including respiratory syncytial virus （RSV）,influenza virusA and B （IFu A and IFu B）,parainfluenza virus 1,2,3 （Para 1,2,3） and adenovirus （ADV）.Results The positive rate of Viral pathogens was 24.3% during the epidemic season from November 2006 to April 2007,while it was 41.8%.from November 2007 to April 2008.Respiratory syncytial virus all occupied the first place in two consecutive years.The positive rate was 20.1% and 32.3% respectively.Conclusion RSV was the most important virus in hospitalized children with respiratory infection in this hospital during winter and spring.ADV and Para Ⅲ took up the second and the third place,while the other viruses were seldom.