氨溴特罗口服液改善毛细支气管炎患儿气道功能疗效研究

Influence of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution on airway function of children with capillary bronchitis

目的探讨氨溴特罗口服液改善毛细支气管炎患儿气道功能的疗效影响。方法将2009年11月至2010年9月广州市妇女儿童医疗中心93例毛细支气管炎患儿随机分为治疗组(氨溴特罗口服液组)和对照组。观察两组患儿治疗前后潮气呼吸流速-容量环(TBFV)的形态改变以及肺功能各项指标的变化。结果两组患儿治疗前TBFV环均变窄,呼气曲线升枝陡峭,高峰提前,降枝呈波谷样凹陷;治疗后明显好转。两组患儿治疗前各项主要参数比较,差异无统计学意义(P>0.05)。两组患儿治疗前后比较:呼吸频率(RR)、呼气峰流速(PEF)、呼吸系统阻力(Rrs)、每千克体重功能残气量(FRC/kg)均降低(P<0.05或P<0.01);每千克体重潮气量(VT/kg)、吸呼比(TI/TE)、呼气达峰时间(TPTEF)、达峰时间比(TPTEF/TE)、呼气达峰容积(VPTEF)、达峰容积比(PFV)、呼出75%潮气量时的呼气流速/呼气峰流速(25/PF)、潮气呼气中期流速/潮气吸气中期流速(ME/MI)、每千克体重顺应性(Crs/kg)均增加(P<0.05或P<0.01)。其中治疗组与对照组比较,反映大小气道阻塞主要指标PFV、25/PF、ME/MI及肺顺应性、气道阻力的Rrs、FRC/kg改善更为明显(P<0.05或P<0.01)。结论氨溴特罗口服液对改善毛细支气管炎患儿气道阻塞有明显的临床疗效。

Objective By observing lung function changes of children with capillary bronchitis after the treatment of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution,access its influence upon airway resistance of children.Methods 93 children with capillary bronchitis were randomly divided into treatment group （with Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution） and control group.Shape changes of TBFV and changes of main indexes of lung function were observed.Results The TBFV of both groups showed narrowing down,abrupt ascending limb on breath curve,peak brought forward,and descending limb sunk like wave trough.After treatment,the shapes of TBFV of both groups were greatly improved.Comparing main parameters of two groups before treatment,there was no marked difference （P 0.05）.After treatment,respiratory rate （RR）,peak expiratory flow （PEF）,respiratory system resistance （Rrs）,and functional residual capacity per kilogram weight （FRC/kg） were all reduced,difference being marked （P0.05）,while tidal volume per kilogram weight （VT/kg）,inspiratory/expiratory （TI/TE）,peak time of expiratory flow （TPTEF）,time to peak ratio （TPTEF/TE）,volume in peak time of expiratory flow （VPTEF）,volume ratio in peak flow （PFV）,MEFR with 75% tidal volume/peak expiratory flow （25/PF）,tidal expiratory interim flow velocity/tidal inspiratory interim flow velocity （ME/MI） and compliance per kilogram weight （Crs/kg）were all increased,difference being marked （P0.05）.Compare treatment group with common group,obvious improvement was shown on airway obstruction main indexPFV,25/PF and ME/MI,and compliance of lung,Rrs of airway resistance,and FRC/kg were obviously improved,the difference also being meaningful.Conclusion Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution shows marked clinical efficacy in improving airway resistance of children with capillary bronchitis.