雷贝拉唑与不同抗生素联用序贯治疗幽门螺杆菌的疗效观察

Efficacy Observation of Sequential Treatment with Rabeprazole Combined with Different Antibiotic on Helicobacter Pylori Infection

目的:观察雷贝拉唑与不同抗生素联用序贯治疗幽门螺杆菌(Hp)的临床疗效。方法:将14C-尿素呼气试验确诊为Hp感染且胃镜证实为消化性溃疡或慢性胃炎的186例患者随机均分为观察组与对照组,观察组给予雷贝拉唑+四环素+克拉霉素连用5d,继以雷贝拉唑+呋喃唑酮+左氧氟沙星连用5d;对照组予雷贝拉唑+阿莫西林+克拉霉素连用10d。疗程结束4周后复查14C-尿素呼气试验。结果:观察组与对照组Hp根治率分别为93.5%、78.5%,2组比较差异有统计学意义(P<0.01);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:雷贝拉唑与不同抗生素联用序贯治疗可显著提高Hp的根治率,不良反应发生率低且轻微。

OBJECTIVE：To observe the efficacy of sequential treatment with rabeprazole combined with different antibiotic on Helicobacter pylori（Hp） infection.METHODS：Hp infection was confirmed by the 14C-urea breath test in 186 peptic ulcer or chronic gastritis patients confirmed by gastroscopy.Patients were randomly divided into observation group and the control group with each of 93 cases.Patients in the observation group were treated with tetracycline＋clarithromycin＋ rabeprazole for 5 days,followed by rabeprazole＋levofloxacin＋furazolidone for 5 days.The control group was treated with rabeprazole＋amoxicillin＋clarithromycin for 10 days.14C-urea breath test was carried out 4 weeks later after the treatment was finished.RESULTS：Hp eradication rate of the observation group and control group were 93.5%,78.5%,respectively（P0.01）.The incidence of side effects of the 2 groups was not statistically different（P0.05）.CONCLUSION：Sequential therapy of rabeprazole combined with different antibiotics can significantly improve the eradication rate of Hp,and show slightly lower incidence of adverse reactions.