期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂氧素在炎症中作用的研究进展 被引量：12

Lipoxins in inflammation:research advances
下载PDF
导出
摘要 脂氧素(lipoxin,LX)是来源于花生四烯酸、经脂氧合酶催化合成的一类生物活性物质。在哺乳动物中,其主要包括脂氧素A4(LXA4)和脂氧素B4(LXB4)。研究表明,在炎症过程中,LX能够抑制白细胞向炎症部位的趋化并促进巨噬细胞吞噬局部凋亡的粒细胞及其他损伤细胞,从而抑制炎症的进程,促进炎症的消退。由于其在炎性疾病中所发挥的独特的抗炎和促进炎症消退的功能而被关注。本文主要介绍近年来LX在合成、代谢、生物学功能及疾病发生中作用的研究进展。 Lipoxin（LX）generates from arachidonic acid via sequential actions of lipoxygenases.In mammals,lipoxygenase enzymes（LOX） generate two main native products： lipoxin A4（LXA4） and lipoxin B4（LXB4）.It has been found that LX could inhibit the inflammatory process through modulating the chemetaxis of leukocyte and promoting the phagocytosis of apoptotic cells by phagocytes.This article reviews the research advances of synthesis,metabolism,biological function and the role of LX in diseases.
作者 胡珊 毛应启梁 王彦青
机构地区 复旦大学上海医学院中西医结合系
出处 《国际药学研究杂志》 CAS 2011年第2期109-111,136,共4页 Journal of International Pharmaceutical Research
基金 国家自然科学基金资助项目(30970975)
关键词 脂氧素 脂氧合酶 抗炎作用 lipoxin lipoxygenases anti-inflammatory effects
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献18

  • 1郭培培,姜远旭,叶习红,吴艳,尚游,袁世荧,姚尚龙.脂氧素A_4对大鼠局部永久性脑缺血的保护作用[J].中国药理学通报,2009,25(10):1304-1308. 被引量：6
  • 2张力,万敬员.脂氧素受体及其介导的促炎症消退信号[J].生命的化学,2007,27(6):545-547. 被引量：11
  • 3Sheng-Hua Wu M.D.,P.-Y. Liao,L. Dong,Z.-Q. Chen.Signal pathway involved in inhibition by lipoxin A4 of production of interleukins induced in endothelial cells by lipopolysaccharide[J]. Inflammation Research . 2008 (9)
  • 4Baker N,O′Meara SJ,Scannell M,et al.Lipoxin A4:anti-in-flammatory and anti-angiogenic impact on endothelial cells. J Immunol . 2009
  • 5Gao YJ,Ji RR.Targeting astrocyte signaling for chronic pain. Neurotherapeutics . 2010
  • 6Sobrado M,Pereira MP,Ballesteros I,et al.Synthesis oflipoxin A4 by 5-lipoxygenase mediates PPARgamma-depen-dent,neuroprotective effects of rosiglitazone in experimentalstroke. The Journal of Neuroscience . 2009
  • 7Pamplona FA,Menezes-de-Lima OJ,Takahashi RN.Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice. Neuroscience Letters . 2010
  • 8Serhan CN.Lipoxins and aspirin-triggered 15-epi-lipoxins arethe first lipid mediators of endogenous anti-inflammation andresolution. Prostaglandins Leukot Essent Fatty Acids . 2005
  • 9Chen K,Le Y,Liu Y,et al.A critical role for the G protein-coupled receptor mFPR2 in airway inflammation and immuneresponses. J Immunol . 2010
  • 10Serhan CN,Yacoubian S,Yang R.Anti-inflammatory and proresolving lipid mediators. Annu Rev Pathol . 2008

二级参考文献36

  • 1张予阳,刘岩,付守廷.脑缺血与炎症反应[J].中国药理学通报,2006,22(1):5-9. 被引量：52
  • 2Christou I,Alexandrov A V,Burgin W S,et al.Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke[J].Stroke,2000,31(8):1812-6.
  • 3Serhan C N,Chiang N,Van Dyke T E.Resolving inflammation:dual anti-inflammatory and pro-resolution lipid mediators[J].Nat Rev Immunol,2008,8(5):349-61.
  • 4Godson C,Mitchell S,Harvey K,et al.Cutting edge:lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages[J].J Immunol,2000,164(4):1663-7.
  • 5Leonard M O,Hannan K,Burne M J,et al.15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester,a synthetic analogue of 15-epi-lipoxin A(4),is protective in experimental ischemic acute renal failure[J].J Am Soc Nephrol,2002,13(6):1657-62.
  • 6Bonnans C,Levy B D.Lipid mediators as agonists for the resolution of acute lung inflammation and injury[J].Am J Respir Cell Mol Biol,2007,36(2):201-5.
  • 7Longa E Z,Weinstein P R,Carlson S,et al.Reversible middle cerebral artery occlusion without craniectomy in rats[J].Stroke,1989,20(1):84-91.
  • 8Paxinos G,Watson C R,Emson P C.AChE-stained horizontal sections of the rat brain in stereotaxic coordinates[J].J Neurosci Methods,1980,3(2):129-49.
  • 9Leker R R,Teichner A,Ovadia H,et al.Expression of endothelial nitric oxide synthase in the ischemic penumbra:relationship to expression of neuronal nitric oxide synthase and vascular endothelial growth factor[J].Brain Res,2001,909(1-2):1-7.
  • 10Touzani O,Boutin H,Chuquet J,et al.Potential mechanisms of interleukin-1 involvement in cerebral ischaemia[J].J Neuroimmunol,1999,100(1-2):203-15.

共引文献15

同被引文献157

引证文献12

二级引证文献43

国际药学研究杂志
2011年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部