摘要
咔唑类化合物是一类重要的芳杂环化合物,在抗细菌、抗真菌和抗病毒方面具有较好的应用前景,深受研究者关注。有关咔唑类化合物的研究包括天然生物碱的分离、全合成、结构修饰及其抗微生物活性研究与开发。本文结合本课题组的研究,综述了近年来咔唑类化合物的抗微生物活性及其构效关系的研究进展。
Carbazole compounds,a class of important aromatic heterocyclic compounds,possess extensive application prospect as antibacterial,antifungal and antiviral agents,and thus receive increasing attention.The researches on carbazole compounds include isolation and total synthesis of naturally carbazole alkaloids,structure modification of carbazole derivatives and investigation on their recovery of antimicrobial activities.This paper reviews recent research advances in carbazole compounds and their antimicrobial activities.The structure-activity relationship is also discussed.
出处
《国际药学研究杂志》
CAS
2011年第2期118-122,141,共6页
Journal of International Pharmaceutical Research
基金
中央高校基本科研业务费专项资金(XDJK2009C092)
重庆市自然科学基金(CSTC2007BB5296)
西南大学人才引进基金(SWUB2006018)
西南大学高新技术培育基金(XSGX0602)
关键词
咔唑
抗细菌
抗真菌
抗病毒
抗微生物
构效关系
carbazole
antibacterial agent
antifungal agent
antiviral agent
antimicrobial agent
structure-activity relationship