具有抗微生物活性咔唑类化合物的研究进展

Antimicrobial activity of carbazole compounds: research advances

咔唑类化合物是一类重要的芳杂环化合物,在抗细菌、抗真菌和抗病毒方面具有较好的应用前景,深受研究者关注。有关咔唑类化合物的研究包括天然生物碱的分离、全合成、结构修饰及其抗微生物活性研究与开发。本文结合本课题组的研究,综述了近年来咔唑类化合物的抗微生物活性及其构效关系的研究进展。

Carbazole compounds,a class of important aromatic heterocyclic compounds,possess extensive application prospect as antibacterial,antifungal and antiviral agents,and thus receive increasing attention.The researches on carbazole compounds include isolation and total synthesis of naturally carbazole alkaloids,structure modification of carbazole derivatives and investigation on their recovery of antimicrobial activities.This paper reviews recent research advances in carbazole compounds and their antimicrobial activities.The structure-activity relationship is also discussed.