芦荟软胶囊的遗传毒性评价

Genetic toxicity assessment of aloe capsule

目的:探讨某品牌芦荟软胶囊的遗传毒性。方法:使用小鼠经口急性毒性试验、小鼠骨髓嗜多染红细胞微核试验、鼠伤寒沙门氏菌回复突变(Ames)试验、和小鼠精子畸形试验对芦荟软胶囊的遗传毒性进行评价。结果:芦荟软胶囊对小鼠的经口急性毒性LD50大于20 ml/kgBW(最大灌胃容量),属实际无毒物质。微核试验、Ames试验和精子畸形试验结果均为阴性。结论:在本次试验条件下,该品牌芦荟软胶囊未显示有遗传毒性作用。

Objective：To study the genetic toxicity of aloe capsule.Methods：A cute toxicity test of mice,micronucleus test of bone marrow PCE cell in mice,Ames test,sperm shape abnormality test of mice.Results：The aloe capsule was a substance with no toxicity according to the acute toxicity.The results of genetic toxicity test were all negative,including micronucleus test,Ames test and sperm shape abnormality test.Conclusion：The aloe capsule has no genetic toxicity in this test.