老年脑梗死患者急性期瘦素动态测定的意义

Clinical significance of detection of serum leptin in elderly patients with acute cerebral infarction

目的探讨老年脑梗死患者急性期瘦素水平的动态变化及其与病情严重性之间的关系。方法 140例老年脑梗死患者,在发病后24 h内入院,分别在入院后第1、3、7天抽取空腹静脉血3 ml,采用放射免疫测定方法动态检测血清瘦素水平,采用欧洲卒中神经功能缺损评分量表(ESS)评价脑梗死的严重程度。同时检测70例健康体检者作为正常对照组。结果老年脑梗死组血清瘦素水平在发病后第1、3、7天均显著高于对照组(P均<0.01),ESS评分与血清瘦素水平无明显相关性(r=0.143,P>0.05)。结论老年脑梗死患者存在高瘦素血症和瘦素抵抗,瘦素水平增高是老年脑梗死的危险标志。

Objective To explore the dynamic change of serum leptin in the elderly patients with cerebral infarction and to analyze the relationship between leptin and the severity of cerebral infarction.Methods 140 elderly patients with acute cerebral infarction were admitted to hospital within 24 hours after stroke.The serum levels of leptin in the patients were measured by radioimmunoassay,and the nervous function was evaluated by European Stroke Scale（ESS） on the 1st,3rd,7th day respectively after hospitalization.At the same time,70 normal adults were enrolled as control group.Results The levels of serum leptin in 140 elderly patients with acute cerebral infarction on the 1st,3rd,7th day were higher than those in the controls（all P0.01）;There was no correlation between serum leptin and ESS scores（r=0.143,P0.05）.Conclusions There is hyperleptinemia and leptin resistance in old patients with acute cerebral infarction.High serum leptin is a risk sign of acute infarction in elderly patients.