46例育龄女性应用人工生物瓣膜置换临床效果分析

Retrospective study on clinical application of biovalves in 46 cases of child-bearing age women

目的分析育龄女性心脏瓣膜疾病异种心脏生物瓣膜置换治疗的临床效果，评价生物瓣膜在育龄女性患者中的应用效果及趋势。方法回顾性分析2005年7月起至2010年1月接受生物瓣膜置换术的46例育龄女性术后生活质量及生育情况。结果平均随访35个月，随访率97．8％。随访病例生存良好，心功能Ⅰ级35例、Ⅱ级9例、Ⅲ级1例。心脏彩超示瓣膜功能良好，无明显衰败迹象。术后怀孕女性33例，自然流产4例，死胎1例，足月顺产21例，早产4例，剖宫产7例，畸胎0例。结论异种心脏生物瓣膜置换对育龄女性疗效确切，在保证手术技术的情况下，术后生活质量及生育情况较好。

Objective To investigate the application of xenograft heart valve replacement in women with heart valve diseases. Methods The quality of life and fertility were retrospective analyzed in 46 female patients of childbearing age undergone biovalve replacement from July 2003 to January 2010. Results The average follow-up was 35 months, follow-up rate was 97.8%. For cardiac function, 35 cases of grade I, I1 grade nine eases, III grade 1 cases. Echocardiogram showed fine heart valve function, no obvious signs of decline. After operation, 33 cases were pregnant, spontaneous abortion in 4 cases, stillbirth in 1 cases, 21 cases of full-term birth, premature delivery in 4 cases, 7 cases of caesarean section, 0 cases of teratogenie. Condusion Xenogeneie biological heart valve replacement has the exact effects in child-bearing age women in ensuring the postoperative quality of life and better fertility.