下腔静脉膜性和节段性阻塞中VEGF表达差异的意义分析

Analysis of VEGF differential expression in membranous obstruction and segmental occlusion with Budd-Chiari syndrome

目的探讨下腔静脉膜性阻塞型布-加综合征(Budd-Chiari syndrome,BCS)患者中血管内皮损伤在隔膜形成过程中发挥的作用;方法采用酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)检测下腔静脉膜性阻塞(Membranous obstruction of inferior vena cava,MOVC)和节段性阻塞患者下腔静脉血液中VEGF的含量,并与非BCS对照组对比进行统计学分析;结果MOVC患者下腔静脉血液中VEGF含量明显高于节段性阻塞BCS患者及非BCS对照组患者,差异有统计学意义(P<0.001);节段性阻塞BCS患者与非BCS对照组患者下腔静脉血液中VEGF无明显差异,差异无统计学意义(P>0.05);结论血管内皮损伤是下腔静脉隔膜形成的激发因素之一。

Objective To investigate whether the vascular endothelial injuried play an important role in the membranaceous formation of the IVC;Methods Detect the serum concentration of VEGF in membranous obstruction and segmental occlusion patients with enzyme-linked immunosorbent assay（ELISA）,and take statistical analysis compared with the control group;Results The serum concentrations of VEGF in membranous obstruction and segmental occlusion patients was singificant difference （P〈0.001） ; the serum concentrations of VEGF in segmental occlusion and the control group patients was not singificant difference （P〉0.05）;Conclusions Vascular endothelium injuried is one of the factors of the formation of membrane.