新疆哈萨克族脑梗塞与ICAM-1基因G241R多态性的关系

The Relationship Between ICAM-1 Gene G241R Polymorphism and Cerebral Infarction in Xinjiang Kazakans

目的:探讨新疆哈萨克族脑梗死与细胞黏附分子1(ICAM-1)G241R基因多态性的关系。方法:采用多聚酶链式反应法及限制性内切酶片段长度多态性技术,对新疆哈萨克族100例脑梗死患者及110例健康者(对照组)进行ICAM-1基因G241R多态性检测,比较不同基因型与哈萨克族脑梗塞发病风险的关系。结果:脑梗塞患者ICAM-1基因G41R多态性的基因型频率和等位基因频率与健康对照组相比无明显差异。结论:ICAM-1基因G214R多态性可能不是新疆哈萨克族脑梗塞发病的遗传学危险因素。

Objective：To investigate the relationship between the polymorphism of ICAM-1 gene K241R and cerebral infarction in Kazakans of Xinjiang.Methods：RePolymerase chain reaction and restriction fragment length polymorphism（PCR-RFLP） methods were used to detect the G241R polymorphism of ICAM-1 gene in Kazakans including 100 patients with cerebral infarction and 110 healthy individuals（control group）.The frequencies of genotype and allele and the association between the genetic polymorphisms and cerebral infarction were analyzed.Results：The prevalence rates of genotype and allele frequency of ICAM-1 gene G241R polymorphism are not significantly different between cerebral infarction and contron group（P0.05）.Conclusion：ICAM-1 gene G241R polymorphism is not associated with cerebral infarction in Kazakans of Xinjiang.