防御素构效关系研究进展

Advances on Structure-activity Relationships of Defensins

防御素是第一大类内源性抗微生物肽,具有广泛的抗菌谱作用,是生物体先天防御系统的重要组成成分。综述了近年国际上对防御素的一级结构、二级结构、三级结构和四级结构及其构效关系研究的最新进展。

Defensins are endogenous antimicrobial polypeptides and have broad wide spectrum of antibacterial activity that play a crucial role in the innate immune system.The primary,secondary,tertiary and quarternary structure of denfensins,and their structure-activity relationships were reviewed.