SiO_2-SO_3H异相催化一步合成9-芳基-3,4,6,7,9,10-六氢吖啶-1,8(2H,5H)-二酮

One-pot synthesis of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione catalyzed by SiO_2-SO_3H

以硅胶磺酸(SiO2-SO3H)为催化剂,4-芳硫基芳醛、1,3-环己二酮及醋酸铵为原料,于乙醇中合成了标题化合物。该方法具有处理方便、反应时间短、产率高、催化剂价廉易得、可回收重复使用等优点。

A highly efficient one-pot synthesis of acridinedione derivatives catalyzed by the silica sulfuric acid in EtOH is reported here.The silica sulfuric acid catalyst（SiO2-SO3H,SSA） is completely heterogeneous and can be recycled for eight consecutive runs without significant loss of activity.This method has several advantages such as simple work-up,environmental friendliness and shorter reaction time along with high yields.