点阵CO_2激光治疗口腔黏膜扁平苔藓的疗效观察

Clinical Study about Oral Lichen Planus Treatment with Fractional CO_2 Laser

通过与传统CO2激光疗法比较,评价点阵CO2激光治疗口腔黏膜扁平苔藓的优劣。方法:经临床和病理检查确诊为口腔黏膜扁平苔藓患者116例,其中A组60例,接受传统CO2激光疗法,B组56例,接受点阵CO2激光疗法。治疗由同一人操作,参数相同:功率5.0W/cm2,照射时间3s,治疗次数3次,每次间隔10周。治疗后观察局部组织反应、脱痂时间、创面愈合时间、治疗区瘢痕形成情况及治愈率。结果:治疗后局部肿痛;A组明显严重于B组;脱痂时间:A组9±0.8天,B组7±0.6天,组间差异非常显著(p<0.01);创面愈合时间:A组11±0.8天,B组8±0.6天,组间差异显著(p<0.05);局部瘢痕:A组较B组明显:治愈率:A组43±7.3%,B组45±6.5%,无显著差异(p>0.05)。结论:与传统CO2,激光比较,点阵CO2激光治疗口腔黏膜扁平苔藓的治愈率相近,但具有创面愈合时间短,局部组织反应轻,瘢痕形成少等优点,值得推广。

Objective To com pare and evaluate the treatment result of oral lichen ptanua（OLP）with CO2 laser and fi＇actional CO2 laser.Method：One hundred and sixteen OLP cases were evaluated in this study.Among these patients,60 and 56 cases were respectively contained in CO2 laser group（group A） and fractional CO2 laser group（group B）.All patients in the two groups were treated three times by the same doctor and the same treatmental parameters.After the treatment,the local tissue reaction,decrustation time,wound heal time,scar,and cure rate were evaluated.Result：The degree of swelling and pain in group A was more severe than in group B.Deerustation time was 9±0.8 days in groupA and 7±0.6 days in group B.（p0.05）.Wound healing time was 11±0.8days in grpup A and 8＋0.6days in group B（p0.05）.The scar in group A was more severe than in group B.The cure rate was 43±7.3%,and 45±6.5% respectively（p0.05）o Conclusion：Compare to traditional CO2 laser,OLP cases which treated with fractional CO2 laser get the similar cure rate,but the swelling,pain and scar are more slight,and the wound healing time is significantly shorten.