电离辐射诱导microRNA研究进展

Progress in research on ionizing radiation-induced microRNA

微小RNA（microRNA,miRNA）是一类长度为21~23 nt的单链非编码小RNA。在真核生物中miRNA主要通过与编码蛋白质基因的信使RNA（mRNA）配对结合,在转录后水平抑制基因表达。越来越多的证据表明,miRNA与氧化应激特别是辐射生物效应相关,miRNA有可能成为放射病治疗的潜在新靶点。本文概述电离辐射诱导miRNA的研究进展。

MicroRNAs（miRNAs）are small single-stranded noncoding RNAs consisting of 21-23 nucleotides that play important gene-regulatory roles in eukaryotes by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression.A growing body of evidence indicates that alterations in miRNA expression may occur following exposure to several oxidative stress including ionizing radiation.So miRNAs may serve as potential new targets for co-therapies aiming to improve the effects of radiation disease therapy in cancer patients.The progress in research on ionizing radiation-induced miRNAs is reviewed in this paper.