潘通治疗急性缺血性中风的疗效观察

OBSERVATION OF CURATIVE EFFECT OF PENTOXIFYLLINE IN TREATMENT OF ACUTE ISCHEMIC STROKE

目的 :探讨潘通 (己酮可可碱 )治疗急性缺血性中风的疗效。方法 :潘通与低分子右旋糖酐 +川芎素进行对照研究 ,治疗急性缺血性中风各 3 9例 ,于 14d和 2 1d分别观察疗效。结果 :潘通治疗组血胆固醇、血小板聚集率、纤维蛋白原和全血粘度 (高切 )有显著差异 ,以血浆粘度改变极其显著 (P <0 .0 0 1) ;对照组经统计学处理血小板聚集率、全血粘度 (高切 )和血浆粘度有显著差异 (P <0 .0 2 ) ;两组总有效率分别为 66.67% ,84 .61%和 5 8.97% ,71.79% ,无显著差异。结论 :潘通治疗急性缺血性中风效果明显 ,不良反应轻微 。

OBJECTIVE:To study the curative effect of pentoxifylline in treatment of acute ischemic stroke.METHODS:78 patients with acute ischemic stroke were equally divided to receive pentoxifylline or low molecular dextran injection and the curative effect at 14d and 21d in both arms were observed.RESULTS:No significant difference in curative effect was observed in both arms but the decrease in plasma viscosity in pentoxifylline arm was significantly lower than that of dextran arm.CONCLUSION:Pentoxifylline is effective in treatment of acute ischemic stroke with mild side effects.