长期血液透析患者庚型肝炎病毒检测100例分析

Measurement and Analysis of Hepatitis G Virus in 100 Cases Long time Hemodialysis Patients

目的 研究血透患者中庚型肝炎病毒（ＨＧＶ）携带情况及影响因素。方法 应用逆转录聚合酶链反应（ＲＴ－ＰＣＲ）方法，对我科血透中心１００ 例长期血透（＞ １ ａ）的患者及４００ 例非血透患者（对照组）血清中ＨＧＶ核糖核酸（ＨＧＶ－ＲＮＡ）进行测定。结果 血透组中２４％ ＨＧＶ－ＲＮＡ阳性，明显高于正常人群的２％ （Ｐ＜ ０．０１）；ＨＧＶ阳性受血率明显增高，分别为７０．８％ 与５１．３％ （Ｐ＜ ０．０１），但均无临床症状；检测１９例ＨＧＶ 阳性血透患者干超滤液，其中均未发现ＨＧＶ－ＲＮＡ。结论 血透患者ＨＧＶ感染率高于普通人群，与输血量有一定相关，病毒不通过聚砜膜。

Objective\ To investigate the pervalence of hepatitis G virus (HGV) infection among hemodialysis patients and evaluate the risk factors of HGV infection in those patients. Methods\ HGV RNA was detected by reverse transcription polymerase chain reaction (RT PCR) assay in 100 patients who were in maintenance hemodialysis and 400 patients without hemodialysis used as control. Results\ 24% of the hemodialysis patients were HGV RNA positive. HGV infection rate in hemodialysis patients was significantly higher than that of control. In HD patients, the frequency of blood transfution in HGV positive patients (70.8%) was significantly higher than in HGV negative patients (51.3%) ( P <0.01). The patients with HGV infection were asymptomatic. However, in 19 HGV positive patients, HGV RNA was not found in ultrafiltrate. Conclusion\ HGV infection rate was high in HD patients and had a close relation with blood transfusion. HGV could not pass through polysulfon.