太原市某医院孕妇尿中1-羟基芘水平与新生儿神经行为评分的关系

Relationship of Urinary 1-Hydroxypyrene Level in Pregnant Women with Physical and Behavioral Development of Their Neonates

[目的]观察太原市某医院孕妇尿中1-羟基芘含量与新生儿神经行为评分的关系,探讨孕期多环芳烃(PAHs)暴露与新生儿神经系统发育的关系。[方法]高效液相色谱法(HPLC)测定2009年7月至2010年5月在太原市某医院生产并签署知情同意书的152名孕妇的尿中1-羟基芘含量,应用新生儿20项神经行为检查法(NBNA)测定新生儿神经行为发育情况,对NBNA得分与孕妇尿中1-羟基芘含量及孕妇一般情况进行多元线性回归分析,验证其相关性。[结果]152名新生儿神经行为得分中位数为38分,其中有4名新生儿神经行为能力未达正常标准(≤35分),新生儿神经行为得分与孕妇尿中1-羟基芘含量、流产次数、孕妇和配偶年龄、居室外35m内有车流量大的干道呈负相关,与妊娠胎次和妊娠前有避孕措施呈正相关。[结论]孕期多环芳烃的暴露可能导致新生儿神经行为评分的降低。

[ Objective ] To investigate the relationship between urinary 1-hydroxypyrene level in pregnant women and scores of Neonatal Behavioral Neurological Assessment （ NBNA ） in a hospital in Taiyuan, to understand the relationship of the pregnant women exposure to PAHs with physical and behavioral development of their neonates. [ Methods ] High-performance liquid chromatography （ HPLC ）with subsequent fluorescence detection was used to determine the urinary 1-hydroxypyrene levels in 152 pregnant women who were living in Taiyuan for more than one year, having their babies in the cooperative hospital at the research time and were willing to cooperate with the researchers. NBNA was used to determine the development of neonatal neural behavior. Using MLR（ Mutiple Linear regression ）to detect the relationship between urinary 1-hydroxypyrene level in the pregnant women and NBNA scores. [ Results ] The median of 152 NBNA scores was 38, in which the NBNA scores of 4 neonates were substandard, less than 35. In multiple linear regression models, there were negative correlations between NBNA scores and urinary 1-hydroxypyrene level, abortion, ages of pregnant women and their husbands, and living near by main traffic roads. There were positive correlations between NBNA scores and number of gestation, and contraception before this gestation. [ Conclusion ] The exposure to PAHs in pregnant women could lead to the reduce of the NBNA scores in their babies. Reducing emission of PAHs to the atmosphere will be significant to physical and behavioral development of neonatus.