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The impact of next-generation sequencing on genomics 被引量：25

The impact of next-generation sequencing on genomics
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摘要 This article reviews basic concepts, general applications, and the potential impact of next-generation sequencing （NGS） technologies on genomics, with particular reference to currently available and possible future platforms and bioinformatics. NGS technologies have demon- strated the capacity to sequence DNA at unprecedented speed, thereby enabling previously unimaginable scientific achievements and novel biological applications. But, the massive data produced by NGS also presents a significant challenge for data storage, analyses, and management solutions. Advanced bioinformatic tools are essential for the successful application of NGS technology. As evidenced throughout this review, NGS technologies will have a striking impact on genomic research and the entire biological field. With its ability to tackle the unsolved challenges unconquered by previous genomic technologies, NGS is likely to unravel the complexity of the human genome in terms of genetic variations, some of which may be confined to susceptible loci for some common human conditions. The impact of NGS technologies on genomics will be far reaching and likely change the field for years to come. This article reviews basic concepts, general applications, and the potential impact of next-generation sequencing （NGS） technologies on genomics, with particular reference to currently available and possible future platforms and bioinformatics. NGS technologies have demon- strated the capacity to sequence DNA at unprecedented speed, thereby enabling previously unimaginable scientific achievements and novel biological applications. But, the massive data produced by NGS also presents a significant challenge for data storage, analyses, and management solutions. Advanced bioinformatic tools are essential for the successful application of NGS technology. As evidenced throughout this review, NGS technologies will have a striking impact on genomic research and the entire biological field. With its ability to tackle the unsolved challenges unconquered by previous genomic technologies, NGS is likely to unravel the complexity of the human genome in terms of genetic variations, some of which may be confined to susceptible loci for some common human conditions. The impact of NGS technologies on genomics will be far reaching and likely change the field for years to come.
作者 Jun Zhang Rod Chiodini Ahmed Badr Genfa Zhang
机构地区 COEfor Neurosciences Department of Biomedical Sciences Internal Medicine College of Life Sciences
出处 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2011年第3期95-109,共15页 遗传学报（英文版）
基金 supported by NINDS/NIH(JZ),Coldwell Foundation(JZ) and TTUHSC(JZ)
关键词 Next-generation sequencing GENOMICS Genetic variation POLYMORPHISM Targeted sequence enrichment BIOINFORMATICS Next-generation sequencing Genomics Genetic variation Polymorphism Targeted sequence enrichment Bioinformatics
分类号 Q78 [生物学—分子生物学] Q811.4 [生物学—生物工程]
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Journal of Genetics and Genomics
2011年 第3期

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