摘要
目的:探讨乙型肝炎病毒(HBV)前S1抗原(Pre-S1)与HBV血清标志物(乙肝五项)之间的关系,并分析联合检测的临床价值。方法:共检测1246例患者血清标本,乙肝五项采用时间分辨荧光免疫技术,Pre-S1采用酶联免疫法,对测定结果进行比较分析。结果:大三阳组前S1抗原(+)检出率为91.1%均高于其他各组,差异有统计学意义(P<0.01),而(HbsAg+、HbeAg-)各组中Pre-S1仍分别有66.7%、48.8%、40.5%的阳性率,HbsAg-组没有检测出Pre-S1+。结论:PreS1是HBV感染与复制的可靠指标,可弥补乙肝五项检测的缺陷,尤其对于HBeAg阴性的乙肝患者临床应用价值更大,二者联合检测有助于乙型肝炎的早期诊断,可以为指导临床治疗提供更及时可靠的实验依据。
Objective:In front of goal discussion second grade hepatitis virus(HBV) the S1 antigen(Pre-S1) with the HBV blood serum designated object(hepatitis B five items) the between relations,and analyzes the union examination the clinical value.Methods: Altogether examines 1246 example patient blood serum specimen,the hepatitis B five items uses the time resolution fluorescence immunity technology,Pre-S1 uses the enzyme joint immunity law,carries on the comparative analysis to the determination result.Results: The big three positive group of front S1 antigen(+) picks out rate is 91.1% is higher than other each group,the difference has statistics significance(P0.01),but(HbsAg+,HbeAg-) each group of Pre-S1 still separately had 66.7%,48.8%,40.5% masculine genders rate,the HbsAg-group has not examined Pre-S1+.Conclusion: PreS1 is the HBV infection and the duplication reliable target,may make up the hepatitis B five examinations the flaws,is especially bigger regarding the HBeAg negative hepatitis B patient clinical practice value,the two union examination is helpful to the second grade hepatitis early diagnosis,may provide the prompt reliable experimental basis for the instruction clinical treatment.
出处
《中国卫生检验杂志》
CAS
2011年第4期939-940,共2页
Chinese Journal of Health Laboratory Technology