尿微量尿白蛋白、血清胱抑素C和糖化血红蛋白三项指标在2型糖尿病肾功能损伤中的临床价值

Three indexes in type 2 diabetes renal damage the clinical value:Urinates the micro albumin,Blood serum Cystatin C and Glycated haemoglobin

目的:探讨2型糖尿病患者肾功能损伤和尿微量尿白蛋白(U-mA lb)、血清胱抑素C(CysC)和糖化血红蛋白(HbALc)三项指标检测结果的关系及临床价值。方法:选择我院内分泌门诊和住院部2型单纯糖尿病(DM)患者50例、2型糖尿病肾病(DN)患者48例以及52例健康体检志愿者,上机检测其糖化血红蛋白、尿微量白蛋白和血清胱抑素C三项指标,并分析评价各项测定结果的关系。结果:DN组的U-mA lb、CysC检测结果明显高于其他两组,差异均有统计学意义(P<0.01),HbALc检测结果高于其他两组(P<0.05);DM组三项结果高于对照组(P<0.05);HbALc与U-mA lb、CysC行水平直线相关分析,均呈正相关(P<0.05)。结论:糖化血红蛋白、尿微量白蛋白和血清胱抑素C三项指标联合检测对诊治2型糖尿病肾功能损伤的临床意义重大。

Objective：Explore in patients with type 2 diabetes renal damage and Urinates the micro albumin（U-mAlb）,blood serum Cystatin C;（CysC C） and glycated hemoglobin（HbALc） three indexes and relationship of testing results of clinical value.Methods： Choose the inpatient hospital endocrine outpatient service and type 2 diabetes mellitus（DM） patients simply 50 cases,type 2 diabetic nephropathy（DN） patients 48 cases and 52 cases with healthy check-up volunteers,computer detecting its glycated hemoglobin,microalbuminuria and Cystatin C three indexes in,and analyzes the relationship between the measuring results of evaluation.Results： MAlb DN group of U-mAlb,CysC detection results,significantly higher than the other two groups are statistically significant difference（P0.01）,HbALc detection results than the other two groups,the difference was statistically significant（P0.05）.DM group than in control group,three results are statistically significant difference（P0.05）.HbALc mAlb,CysC with U-do all related analysis,straight and level positively correlated（P0.05）.Conclusion： Glycated hemoglobin,glutathione microalbuminuria and serum Cystatin C three indexes of united detection diagnosis of renal damage type 2 diabetes clinical significance.