奥美拉唑对多潘立酮在大鼠体内药动学的影响

Effect of Omeprazole on Pharmacokinetics of Domperidone in Rats

目的研究奥美拉唑对多潘立酮在大鼠体内药动学的影响。方法 10只健康雄性Wistar大鼠随机分成2组(分别为单独和联合给药组),用LC-MS/MS测定血浆中多潘立酮的浓度。结果单独用药与联合用药组tmax分别为(0.80±0.11),(1.20±0.45)h,ρmax分别为(103.0±26.6),(72.6±9.23)μg.L-1,均具有显著性差异(P<0.05),其他药动学参数无显著性差异(P>0.05)。结论联合用药后奥美拉唑延缓了多潘立酮的吸收速度。

OBJECTIVE To investigate the effect of omeprazole on the pharmacokinetics of domperidone in rats. METHODS Ten healthy male Wistar rats were divided into 2 groups and received i. g. administration of domperidone alone or combination of omeprazole and domperidone, respectively. The plasma concentration of dompefidone was determined by LC-MS/MS. RESULTS The pharmacokinetic parameters of dompefidone in healthy rats after i.g. administration of domperidone alone and combination of omeprazole and domperidone were as follows ： tmax （ 0. 80 ± 0. 11 ） and （ 1.20 ± 0. 45 ） h, Pmax （ 103.0 ± 26. 6 ） and （72. 6 ± 9. 23 ） μg · L^-1 （ p 〈 0. 05 ）, There was no significant difference for the other pharmacokineties parameters between the 2 groups （ P 〉 0. 05 ）. CONCLUSION The absorption of domperidone was delayed and decreased when coadministered with omeprazole.