胆木叶化学成分研究

Study on chemical constituents from leaves of Naudea officinalis

目的:研究胆木叶的化学成分。方法:采用柱色谱法和半制备高效液相色谱法进行分离和纯化,通过波谱分析鉴定其化学结构。结果:分离得到5个已知化合物,分别为异长春花苷内酰胺(strictosamide,1),10-羟基异长春花苷内酰胺(10-hydroxy strictosamide,2),山奈酚-3-O-芸香糖苷(kaempferol-3-O-rutinoside,3),芦丁(rutin,4),短小蛇根草苷(pumiloside,5)。结论:化合物2,3,4是首次从胆木叶中分离得到。

Objective： To study the chemical constituents of the leaves of Naudea officinalis. Method： The chemical constituents were separated by column chromatography and semi-preparative HPLC techniques, and their structures were determined by spectral analysis. Result： Five compounds were isolated and identified as strictosanlide（1）, 10-hydroxy strictosamide（2）, kaempferol-3-O-rutinoside（3）, rutin （4）, pumiloside（5）. Conclusion： Among these compounds, 2, 3, 4 are isolated from the leaves of Naudea officinalis for the first time.